"FOOD" for thought??... CWD & Never eating venison again?!?!?

Discussion in 'Iowa Whitetail Conference' started by Sligh1, Jan 20, 2019.

  1. 7mmsendero

    7mmsendero New Member

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    Does she eat any beef or lamb? It would be interesting to know this, because none of the above seems her only safe option.
     
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  3. 7mmsendero

    7mmsendero New Member

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    Does she eat any beef or lamb? It would be

    Cervid to human prion transmission

    Kong, Qingzhong

    Case Western Reserve University, Cleveland, OH, United States

    Abstract

    Prion disease is transmissible and invariably fatal. Chronic wasting disease (CWD) is the prion disease affecting deer, elk and moose, and it is a widespread and expanding epidemic affecting 22 US States and 2 Canadian provinces so far. CWD poses the most serious zoonotic prion transmission risks in North America because of huge venison consumption (>6 million deer/elk hunted and consumed annually in the USA alone), significant prion infectivity in muscles and other tissues/fluids from CWD-affected cervids, and usually high levels of individual exposure to CWD resulting from consumption of the affected animal among often just family and friends. However, we still do not know whether CWD prions can infect humans in the brain or peripheral tissues or whether clinical/asymptomatic CWD zoonosis has already occurred, and we have no essays to reliably detect CWD infection in humans.

    We hypothesize that:

    (1) The classic CWD prion strain can infect humans at low levels in the brain and peripheral lymphoid tissues;

    (2) The cervid-to-human transmission barrier is dependent on the cervid prion strain and influenced by the host (human) prion protein (PrP) primary sequence;

    (3) Reliable essays can be established to detect CWD infection in humans; and

    (4) CWD transmission to humans has already occurred. We will test these hypotheses in 4 Aims using transgenic (Tg) mouse models and complementary in vitro approaches.

    Aim 1 will prove that the classical CWD strain may infect humans in brain or peripheral lymphoid tissues at low levels by conducting systemic bioassays in a set of humanized Tg mouse lines expressing common human PrP variants using a number of CWD isolates at varying doses and routes. Experimental human CWD samples will also be generated for Aim 3.

    Aim 2 will test the hypothesis that the cervid-to-human prion transmission barrier is dependent on prion strain and influenced by the host (human) PrP sequence by examining and comparing the transmission efficiency and phenotypes of several atypical/unusual CWD isolates/strains as well as a few prion strains from other species that have adapted to cervid PrP sequence, utilizing the same panel of humanized Tg mouse lines as in Aim 1.

    Aim 3 will establish reliable essays for detection and surveillance of CWD infection in humans by examining in details the clinical, pathological, biochemical and in vitro seeding properties of existing and future experimental human CWD samples generated from Aims 1-2 and compare them with those of common sporadic human Creutzfeldt-Jakob disease (sCJD) prions.

    Aim 4 will attempt to detect clinical CWD-affected human cases by examining a significant number of brain samples from prion-affected human subjects in the USA and Canada who have consumed venison from CWD-endemic areas utilizing the criteria and essays established in Aim 3. The findings from this proposal will greatly advance our understandings on the potential and characteristics of cervid prion transmission in humans, establish reliable essays for CWD zoonosis and potentially discover the first case(s) of CWD infection in humans.

    Public Health Relevance

    There are significant and increasing human exposure to cervid prions because chronic wasting disease (CWD, a widespread and highly infectious prion disease among deer and elk in North America) continues spreading and consumption of venison remains popular, but our understanding on cervid-to-human prion transmission is still very limited, raising public health concerns. This proposal aims to define the zoonotic risks of cervid prions and set up and apply essays to detect CWD zoonosis using mouse models and in vitro methods. The findings will greatly expand our knowledge on the potentials and characteristics of cervid prion transmission in humans, establish reliable essays for such infections and may discover the first case(s) of CWD infection in humans.

    Funding Agency
    Agency
    National Institute of Health (NIH)

    http://grantome.com/grant/NIH/R01-NS088604-04

    ZOONOTIC CHRONIC WASTING DISEASE CWD TSE PRION UPDATE

    here is the latest;

    PRION 2018 CONFERENCE

    Oral transmission of CWD into Cynomolgus macaques: signs of atypical disease, prion conversion and infectivity in macaques and bio-assayed transgenic mice

    Hermann M. Schatzl, Samia Hannaoui, Yo-Ching Cheng, Sabine Gilch (Calgary Prion Research Unit, University of Calgary, Calgary, Canada) Michael Beekes (RKI Berlin), Walter Schulz-Schaeffer (University of Homburg/Saar, Germany), Christiane Stahl-Hennig (German Primate Center) & Stefanie Czub (CFIA Lethbridge).

    To date, BSE is the only example of interspecies transmission of an animal prion disease into humans. The potential zoonotic transmission of CWD is an alarming issue and was addressed by many groups using a variety of in vitro and in vivo experimental systems. Evidence from these studies indicated a substantial, if not absolute, species barrier, aligning with the absence of epidemiological evidence suggesting transmission into humans. Studies in non-human primates were not conclusive so far, with oral transmission into new-world monkeys and no transmission into old-world monkeys. Our consortium has challenged 18 Cynomolgus macaques with characterized CWD material, focusing on oral transmission with muscle tissue. Some macaques have orally received a total of 5 kg of muscle material over a period of 2 years.
    After 5-7 years of incubation time some animals showed clinical symptoms indicative of prion disease, and prion neuropathology and PrPSc deposition were detected in spinal cord and brain of some euthanized animals. PrPSc in immunoblot was weakly detected in some spinal cord materials and various tissues tested positive in RT-QuIC, including lymph node and spleen homogenates. To prove prion infectivity in the macaque tissues, we have intracerebrally inoculated 2 lines of transgenic mice, expressing either elk or human PrP. At least 3 TgElk mice, receiving tissues from 2 different macaques

    THAT The Majority of cases were male (60%), AND half of them had exposure to wild game.

    snip...

    see more on Prion 2017 Macaque study from Prion 2017 Conference and other updated science on cwd tse prion zoonosis below...terry

    https://prion2018.org/wp-content/uploads/2018/05/program.pdf

    https://prion2018.org/

    THURSDAY, OCTOBER 04, 2018

    Cervid to human prion transmission 5R01NS088604-04 Update

    http://grantome.com/grant/NIH/R01-NS088604-04

    http://chronic-wasting-disease.blogspot.com/2018/10/cervid-to-human-prion-transmission.html

    Saturday, December 15, 2018

    ***> ADRD Summit RFI Singeltary COMMENT SUBMISSION BSE, SCRAPIE, CWD, AND HUMAN TSE PRION DISEASE December 14, 2018

    https://prionprp.blogspot.com/2018/12/adrd-summit-rfi-singeltary-comment.html

    http://chronic-wasting-disease.blogspot.com/2018/10/cervid-to-human-prion-transmission.html

    Saturday, December 15, 2018

    ***> ADRD Summit RFI Singeltary COMMENT SUBMISSION BSE, SCRAPIE, CWD, AND HUMAN TSE PRION DISEASE December 14, 2018

    https://prionprp.blogspot.com/2018/12/adrd-summit-rfi-singeltary-comment.html


    kind regards, terry[/QUOTE]

    Something to consider (hopefully it is researched soon) is the fact more women are vegetarians than men. Could the 60% male CJD in the study correlate with the the ratio make to female vegetarians?

    One thing that seems pretty obvious, these diseases are more likely to occur in those that eat meat.
     
  4. loneranger

    loneranger Well-Known Member

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    Said already. But if meat eaters are subject. Coyotes wolves. Bear. Mountain lion. All should be dyin too. They consume the entire deer. Elk. Moose.
     
  5. Sligh1

    Sligh1 Administrator Staff Member

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    IF YOU FOLLOW THE SCIENCE, there is no such thing as 0% risk on eating meat with the prion issue. Period. So, there's a chance you could DIE!!! I also do NOT want to tell someone what to do or not to do... not my place, expertise & there's risks with anything. Of course, anyone should be minimizing risks with any dangerous issue. Look at some facts here....
    YOU COULD DIE!!!!! I'm not minimizing these horrible things, just laying them out to understand some data & statistics, data is YEARLY....
    1) Creutzfeldt-Jakob disease, a Prion disease - This source cites 350 cases in the US per year, most at 60 years old get it and 70% die. About 1 in 1 million you get this disease based on this data. Or .0001% chance you get this. https://www.cdc.gov/prions/cjd/occurrence-transmission.html -
    https://www.ninds.nih.gov/Disorders...t-Sheets/Creutzfeldt-Jakob-Disease-Fact-Sheet
    2) A case against produce, chicken, ground beef, etc. https://www.cdc.gov/salmonella/index.html Higher incidence but lower death. Salmonella causes 450 deaths per year in US. About a .00013% chance you DIE of this.
    3) LISTERIA. https://www.cdc.gov/listeria/risk.html Food related illness, 250 deaths per year in US. .00007% chance you die from this.
    4) CDC Data for food-borne illness overall in the US. https://wwwnc.cdc.gov/eid/article/5/5/99-0502_article "76 million illnesses, 325,000 hospitalizations, and 5,000 deaths in the United States each year". Overall, a .00014% chance of of death.
    5) "Winter Related Deaths".... https://www.usatoday.com/story/weather/2014/07/30/weather-death-statistics-cold-heat/13323173/ - CDC has it at about 2,000 deaths per year. .00057% chance of death.

    No one wants any of these things & should avoid getting them. Important to understand the risks. Interesting to see the scale & scope of each. If you want to worry about EVERYTHING!!!! ;)... go research the risks of you getting killed in car accident, getting addicted to drugs & dying. One statistic that really freaked me out!!.... With enough years... A simple Graph with X & Y Axis... PROVE!!!.... With enough years added to your life, the risk of death increases & eventually becomes 100% DEATH!!!:eek:

    Enjoy the day all! :)
     
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  6. turkeyriver

    turkeyriver PMA Member

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    Good post Sligh. Of the the 350 cases of CJD a year, how many are linked to eating some other species with a prion disease? They don't know or aren't telling. I can get myself all worked up about CWD and think I shouldn't eat any more venison(I'm in a zone with it). But when I look at all the things in this world that can kill me, I realize I could die in a car accident much more surely than catch CWD. I sure as hell am not going to eat brains out of an infected deer, just as I'm not going to drive 100mph on an icy road! This reminds me of the gun banning crowd screaming about gun deaths when you're more likely to drown in a swimming pool or from a fall in your bathtub or from smoking or pick your poison. CWD is serious as hell, especially if you are a deer, but I'm more scared of my kids starving to death in a socialist USA, than I am of eating deer.(Sorry, been reading too much about the Democratic Socialist party lately) I have been and will continue to go through the hassle of testing every deer I eat because to me that's common sense and I believe more people die prematurely every year from a lack of common sense than from all other causes combined!
     
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  7. bluedog69

    bluedog69 Member

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    That is a recent article. I am going off of an article I read 20+ years ago about many people in OH IN IL TN area that were frequent squirrel brain eaters that had cjd.
     
  8. 7mmsendero

    7mmsendero New Member

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    Agree, and I think there’s a lot going on with what and what organs you eat that we don’t fully understand.

    I’m a scientist by training and have known about prions for a couple of decades. Often I sit back and think the simple answer is God doesn’t like cannibalism. Mad Cow and CJD have links to cannibalism, it makes you wonder.
     
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  9. Hardwood11

    Hardwood11 Well-Known Member

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    Great point on the Socialists!! Don’t think for a minute they would not go after private property rights as well!
     
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  10. loneranger

    loneranger Well-Known Member

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    You would think with all the money revolving around deer hunting that a great amount would be invested from all with a vested interest to find a cure.
     
  11. bluedog69

    bluedog69 Member

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    Or is the risk being blown out of proportion? I don’t know for sure but I sure don’t trust any experts.
     
  12. loneranger

    loneranger Well-Known Member

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    Yea not sure who to believe ? but the speakers from Wisconsin and Colorado , and all of their research charts ,were and are hard to ignore.
     
  13. loneranger

    loneranger Well-Known Member

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    Not talking now about humans getting it but the effects on deer numbers and hunting.
     
  14. Bowman D

    Bowman D Member

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    With this being on the radar for so many states, they need put more funding into finding a test with real time results. I realize this is not a cure, but it would stop the possibility of meat coming to a processor and infecting others, and the hunter would know to dispose of the carcass right away and in the correct fashion.
     
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  15. bluedog69

    bluedog69 Member

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    There are three kinds of lies in this world.

    Lies.
    Damn lies.
    And statistics.

    Data and science can be collected, used, ignored, and manipulated. Hence the third and worst kind of lie... statistics.
     
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  16. loneranger

    loneranger Well-Known Member

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    Don’t think the people in the symposium videos were manipulating.
     
  17. bluedog69

    bluedog69 Member

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    How do we know they aren’t? Seriously? They tell us XYZ about tests and positives and how many. How do we know they are being truthful?
     
  18. Fishbonker

    Fishbonker Life Member

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    How does anybody believe anything? We listen, we evaluate, we believe based on our past experiences, our education and faith or trust in the people delivering the message.
     
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  19. Mike311

    Mike311 Active Member

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    Like everyone so far I’m not sure what the answers are. I remember as a kid, 41 now, the AIDS epidemic blowing up and now you rarely hear anything about it. A solution as to how not to contract it came about and eventually medicines to slow the progression of the disease as well. We live until we die I guess.
     
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  20. Sligh1

    Sligh1 Administrator Staff Member

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    I agree. It is frustrating. I agree with several above though on how, in science & anywhere- data is manipulated to fit your narrative, bias or agenda. I’ve seen it for years & does happen.

    Here’s common ground at least.....
    Cwd is real. Prions exist & harmful to animals. We all would love to see it cured. There’s nothing good about it. It obviously has ability to spread based on both sides of debate.
    Hope there is a cure & hope we continue to understand it far better than we do today. I’m very “concerned” about how we deal with it until that point. Above is where at least both sides can agree & move forward with “discussion, “management” & debate” though.
     
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