It looks like mastitis. I have seen it in cattle. If i remember right it usually happens after a calf has been weaned then an infection sets in one of the quarters and spreads. It looks like she has had an infection for some time before the first picture was taken. That's just my guess.
We had a dog that developed fat tumors as he got older, the biggest one was about the size of a volleyball, that would be my guess. That or alien pod baby....
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